Health and Nutrition

November 28, 2011

Low Serum Vitamin D Levels and Recurrent Inflammatory Spinal Cord Disease

Filed under: Vitamin D — Doc Joe @ 3:29 pm

Maureen A. Mealy, RN, BSN; Scott Newsome, DO; Benjamin M. Greenberg, MD, MHS; Dean Wingerchuk, MD, MSc; Peter Calabresi, MD; Michael Levy, MD, PhD

Arch Neurol. Published online November 14, 2011. doi:10.1001/archneurol.2011.1974

Background  Low 25-hydroxyvitamin D levels have been associated with a higher risk of developing multiple sclerosis and increased relapse rates in patients with multiple sclerosis. As a sterol hormone involved in multiple immunologic pathways, vitamin D may play a role in preventing monophasic immune-mediated central nervous system attacks from developing into recurrent disease.

Objective  To investigate the association between low serum vitamin D levels and recurrent spinal cord disease.

Design, Setting, and Patients  We performed a retrospective analysis at Johns Hopkins Transverse Myelitis Center, Baltimore, Maryland, evaluating 25-hydroxyvitamin D levels in 77 patients with monophasic and recurrent inflammatory diseases of the spinal cord.

Main Outcome Measure  Levels of 25-hydroxyvitamin D.

Results  Vitamin D levels are significantly lower in patients who developed recurrent spinal cord disease, adjusting for season, age, sex, and race.

Conclusions  This study provides a basis for a prospective trial of measuring 25-hydroxyvitamin D levels in these patient populations and assessing the influence of vitamin D supplementation on the frequency of relapses in those with recurrent inflammatory spinal cord disease.

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