Health and Nutrition

December 17, 2018

The effect of curcumin (turmeric) on Alzheimer’s disease: An overview

Filed under: General Health,Herbal Remedies,Nutrition — Doc Joe @ 4:49 pm

Ann Indian Acad Neurol. 2008 Jan-Mar; 11(1): 13–19.doi:  [10.4103/0972-2327.40220: 10.4103/0972-2327.40220]PMCID: PMC2781139PMID: 19966973

Shrikant Mishra and Kalpana PalaniveluDepartment of Neurology, VA/USC 16111, Sepulveda, CA, USAFor correspondence: Shrikant Mishra, Department of Neurology, VA/USC 16111, Plummer Street, Sepulveda, CA, 91343 USA. E-mail: ude.csu@arhsimsReceived 2007 Nov 4; Revised 2008 Feb 5; Accepted 2008 Feb 12

Abstract

This paper discusses the effects of curcumin on patients with Alzheimer’s disease (AD). Curcumin (Turmeric), an ancient Indian herb used in curry powder, has been extensively studied in modern medicine and Indian systems of medicine for the treatment of various medical conditions, including cystic fibrosis, haemorrhoids, gastric ulcer, colon cancer, breast cancer, atherosclerosis, liver diseases and arthritis. It has been used in various types of treatments for dementia and traumatic brain injury. Curcumin also has a potential role in the prevention and treatment of AD. Curcumin as an antioxidant, anti-inflammatory and lipophilic action improves the cognitive functions in patients with AD. A growing body of evidence indicates that oxidative stress, free radicals, beta amyloid, cerebral deregulation caused by bio-metal toxicity and abnormal inflammatory reactions contribute to the key event in Alzheimer’s disease pathology. Due to various effects of curcumin, such as decreased Beta-amyloid plaques, delayed degradation of neurons, metal-chelation, anti-inflammatory, antioxidant and decreased microglia formation, the overall memory in patients with AD has improved. This paper reviews the various mechanisms of actions of curcumin in AD and pathology.

Keywords: Alternative approach to Alzheimer’s, beta amyloid plaques, curcumin, curcumin and dementia, epidemiology, turmeric

December 30, 2014

Grape seed extract is a powerful antioxidant

Filed under: General Health,Herbal Remedies,Nutrition — Doc Joe @ 6:55 pm

May 9, 2009

Green Tea Extract May Improve Recovery from Injury

Filed under: General Health,Herbal Remedies,Nutrition — Doc Joe @ 4:28 pm

Breaking News

In a recently published study, green tea extract was investigated in an experimental model of spinal cord injury.

In this study, mice were subjected to spinal cord trauma by a spinal operation called a laminectomy, in which the area of the vertabrae called the lamina is removed. This operation resulted in increased measures of inflammation and edema, infiltration of white blood cells called neutrophils, and programmed cell death, also known as apoptosis. There were also significantly increased levels of nitrotyrosine, which is used as a marker of cell damage, inflammation, and nitric oxide production. Green tea extract was administered one and six hours after the spinal cord injury.

The mice receiving green tea extract demonstrated a reduction in all of the measures of inflammation. There was a significant decrease in the degree of spinal cord inflammation and reductions in levels of nitrotyrosine, less infiltration by neutrophils, and lower levels of poly ADP-ribosyl synthetase, which is an enzyme involved in apoptosis and DNA repair. Additionally, the recovery of limb function was significantly ameliorated by green tea extract.

The study authors stated, “Taken together, our results clearly demonstrate that green tea extract treatment ameliorates spinal cord injury oxidative stress.”

Reference:

Paterniti I, Genovese T, Crisafulli C, Mazzon E, Di Paola R, Galuppo M, Bramanti P, Cuzzocrea S. Treatment with green tea extract attenuates secondary inflammatory response in an experimental model of spinal cord trauma. Naunyn Schmiedebergs Arch Pharmacol. 2009 Apr 1. Published Online Ahead of Print.

Individuals who do not want to consume large amounts of green tea as a beverage can take green tea extract capsules

February 1, 2009

Grape seed extract may help prevent skin cancer

Filed under: General Health,Herbal Remedies,Nutrition — Doc Joe @ 6:55 pm

Mon Mar 26, 2007 3:34pm EDT

NEW YORK (Reuters Health) – Chemicals found in grape seeds may help ward of skin cancer due to regular exposure to the sun, according to the results of an animal study reported Sunday in Chicago at the 223rd annual meeting of the American Chemical Society.

Researchers from the University of Alabama, Birmingham exposed hairless mice to ultraviolet-light. Some of the mice they fed a standard diet supplemented with grape seed proanthocyanidins, or GSPs, while control mice were fed a standard diet without this supplement.

Dietary supplementation with GSPs inhibited light-induced carcinogenesis, study chief Dr. Santosh K. Katiyar told the conference.

Mice supplemented with GSPs had up to 65 fewer tumors than control mice did. Moreover, the tumors seen in GSP-supplemented mice were up to 78 percent smaller than those seen in the control mice. (more…)

March 2, 2006

Ginkgo biloba extract: More than just for memory?

Filed under: Herbal Remedies — Doc Joe @ 4:55 pm

Public release date: 23-Feb-2006

Contact: Laura Cavender
lsc6@georgetown.edu
202-687-5100
Georgetown University Medical Center
Washington, DC — Researchers at Georgetown University Medical Center say they now have a clearer picture of how an extract from the leaves of the Ginkgo biloba tree reduces the risk of aggressive cancer in animal experiments.

In the January-February issue of the journal Anticancer Research, the investigators reported that treating mice with an extract of leaves of Ginkgo biloba both before and after implanting human breast or brain (glioma) tumors decreased expression of a cell receptor associated with invasive cancer. This decreased expression slowed the growth of the breast tumors by 80 percent as long as the extract was used, compared to untreated mice, and also reduced the size of the brain tumors, but temporarily, and to a lesser extent.

Ginkgo biloba extract is a popular supplement that comes from the leaves of the Gingko tree, which is indigenous to Japan, Korea and China but can be found all over the world. Many believe it enhances memory, and is being currently being tested as a treatment for Alzheimer’s disease.

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December 19, 2005

Primrose oil component cuts levels of cancer-causing gene Her-2/neu

Filed under: Herbal Remedies,Nutrition — Doc Joe @ 7:40 pm

Public release date: 1-Nov-2005

Gamma-linolenic acid (GLA), a substance in evening primrose oil and several other plant oils used in herbal medicine, inhibits action of Her-2/neu, a cancer gene that is responsible for almost 30 percent of all breast cancers, Northwestern University researchers report.

“Breast cancer patients with Her-2/neu-positive tumors have an aggressive form of the disease and a poor prognosis,” said Ruth Lupu, director of Evanston Northwestern Healthcare Breast Cancer Translational Research Program, who led the study, published in the Nov. 2 issue of the Journal of the National Cancer Institute.

Lupu is professor of medicine at Northwestern University Feinberg School of Medicine and a researcher at The Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

(more…)

December 8, 2005

Hops rich in anti-cancer compounds

Filed under: General Health,Herbal Remedies — Doc Joe @ 7:58 pm

18/11/2005- New research into a flavonoid compound found only in hops shows that it may help prevent cancer if a method to improve its absorption in the body can be found.

The anti-cancer activity of xanthohumol was first discovered around 10 years ago by a team at Oregon State University in the US.

But although some brewers are now marketing products enriched in the compound, such as Germany’s Xam, the US researchers say beer is unlikely to offer any anti-cancer benefits.

Fred Stevens, based at Oregon’s Linus Pauling Institute, told NutraIngredients.com: “Even with higher levels of xanthuomol in beer it is very hard to get the levels we tested in cell cultures into the bloodstream.”

“Absorption is very limited and even if it was all absorbed, there is very active metabolism. The xanthuomol is mostly glucaronated.”

Nevertheless, Stevens believes the findings are promising enough to merit further research, and also to look at different methods of consumption.

“If you put the compound in a capsule, that’s a whole different story,” he said.

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July 25, 2005

St John’s Wort Vindicated

Filed under: Herbal Remedies — Doc Joe @ 7:04 pm

Three years ago, the results of a study examining St. John’s sort (Hypericum perforatum) versus a popular antidepressant (Zoloft) appeared n the widely read Journal of the American Medical Association (JAMA). Media coverage of this study blared: “St. John’s Wort Ineffective for Depression.”

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